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Multifunctional Hybrid Nanoparticles for Traceable Drug Delivery and Intracellular Microenvironment‐Controlled Multistage Drug‐Release in Neurons
Author(s) -
Shi Bingyang,
Du Xin,
Chen Jian,
Fu Libing,
Morsch Marco,
Lee Albert,
Liu Yong,
Cole Nicholas,
Chung Roger
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201603966
Subject(s) - drug delivery , drug , nanotechnology , nanoparticle , mesoporous silica , controlled release , targeted drug delivery , dendrimer , drug carrier , intracellular , materials science , chemistry , pharmacology , mesoporous material , medicine , biochemistry , catalysis
Innovative nanoparticles hold promising potential for disease therapy as drug delivery systems. For brain‐disease therapy, a drug delivery system that can sustainably control drug‐release and monitor fluorescence of the drug cargos is highly desirable. In this study, a light‐traceable and intracellular microenvironment‐responsive drug delivery system was developed based on the combination of glutathione‐responsive autoflurescent nanogel, dendrimer‐like mesoporous silica nanoparticles, and gold nanoparticles. The resulting hybrid nanoparticles represent a new class of delivery system that can efficiently load, transport, and control multistage‐release of sulfydryl‐containing drugs into neurons, with light‐traceable monitoring for future brain‐disease therapy.