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Light‐Triggered Inactivation of Enzymes with Photothermal Nanoheaters
Author(s) -
Thompson Sebastian A.,
Paterson Sureyya,
Azab Marwa M. M.,
Wark Alastair W.,
de la Rica Roberto
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201603195
Subject(s) - nanorod , enzyme , photothermal therapy , plasmon , nanotechnology , computer science , photothermal effect , chemistry , biochemistry , computational biology , materials science , biology , optoelectronics
A universal method for inactivating enzymes on demand is introduced, which involves irradiating nanorod‐bound enzymes with near‐infrared light. The subsequent generation of plasmonic heat denatures the enzymes selectively without damaging other proteins or cell membranes present in the same solution.