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Rattle‐Structured Upconversion Nanoparticles for Near‐IR‐Induced Suppression of Alzheimer's β‐Amyloid Aggregation
Author(s) -
Kuk Sukeun,
Lee Byung Il,
Lee Joon Seok,
Park Chan Beum
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201603139
Subject(s) - nanoparticle , rose bengal , photon upconversion , nanotechnology , cytotoxicity , amyloid (mycology) , nanocrystal , chemistry , computer science , materials science , optoelectronics , biochemistry , organic chemistry , doping , inorganic chemistry , in vitro
Rose bengal (RB)‐loaded upconverting nanocomposites are synthesized as a near‐infrared (NIR)‐responsive inhibitor of Aβ aggregation. Rattle‐structured, organosilica shell (ROS) is deposited on NaYF 4 :Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self‐assembly under NIR irradiation by generating 1 O 2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ‐induced cytotoxicity.