Rattle‐Structured Upconversion Nanoparticles for Near‐IR‐Induced Suppression of Alzheimer's β‐Amyloid Aggregation | Zendy

Kuk Sukeun | Zendy; Lee Byung Il | Zendy; Lee Joon Seok | Zendy; Park Chan Beum | Zendy

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Rattle‐Structured Upconversion Nanoparticles for Near‐IR‐Induced Suppression of Alzheimer's β‐Amyloid Aggregation

Author(s) -

Kuk Sukeun,

Lee Byung Il,

Lee Joon Seok,

Park Chan Beum

Publication year - 2017

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201603139

Subject(s) - nanoparticle , rose bengal , photon upconversion , nanotechnology , cytotoxicity , amyloid (mycology) , nanocrystal , chemistry , computer science , materials science , optoelectronics , biochemistry , organic chemistry , doping , inorganic chemistry , in vitro

Rose bengal (RB)‐loaded upconverting nanocomposites are synthesized as a near‐infrared (NIR)‐responsive inhibitor of Aβ aggregation. Rattle‐structured, organosilica shell (ROS) is deposited on NaYF 4 :Yb,Er nanocrystals (UCNPs) for high loading efficiency and disaggregation of RB. RB/UCNP@ROS successfully inhibits Aβ self‐assembly under NIR irradiation by generating 1 O 2 . Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Aβ‐induced cytotoxicity.

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