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Branched Gold Nanoparticle Coating of Clostridium novyi ‐NT Spores for CT‐Guided Intratumoral Injection
Author(s) -
Park Wooram,
Cho Soojeong,
Huang Xiaoke,
Larson Andrew C.,
Kim DongHyun
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201602722
Subject(s) - nanoparticle , spore , colloidal gold , coating , computed tomography , materials science , computer science , nanotechnology , medicine , radiology , microbiology and biotechnology , biology
Branched gold nanoparticle (BGNP)‐coated Clostridium novyi‐ NT ( C. novyi ‐NT) spores are developed for computed tomography (CT)‐guided bacteriolytic tumor therapy. The BGNP‐coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor‐bearing mouse model.