Branched Gold Nanoparticle Coating of  Clostridium novyi ‐NT Spores for CT‐Guided Intratumoral Injection | Zendy

Park Wooram | Zendy; Cho Soojeong | Zendy; Huang Xiaoke | Zendy; Larson Andrew C. | Zendy; Kim DongHyun | Zendy

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Branched Gold Nanoparticle Coating of Clostridium novyi ‐NT Spores for CT‐Guided Intratumoral Injection

Author(s) -

Park Wooram,

Cho Soojeong,

Huang Xiaoke,

Larson Andrew C.,

Kim DongHyun

Publication year - 2017

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201602722

Subject(s) - nanoparticle , spore , colloidal gold , coating , computed tomography , materials science , computer science , nanotechnology , medicine , radiology , microbiology and biotechnology , biology

Branched gold nanoparticle (BGNP)‐coated Clostridium novyi‐ NT ( C. novyi ‐NT) spores are developed for computed tomography (CT)‐guided bacteriolytic tumor therapy. The BGNP‐coated spores are successfully injected into a tumor site under CT image guidance. As a result, a strong antitumor effect is observed in a PC3 prostate tumor‐bearing mouse model.

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