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Targeted Co‐delivery of PTX and TR3 siRNA by PTP Peptide Modified Dendrimer for the Treatment of Pancreatic Cancer
Author(s) -
Li Yang,
Wang Hebin,
Wang Kai,
Hu Qinglian,
Yao Qi,
Shen Youqing,
Yu Guocan,
Tang Guping
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201602697
Subject(s) - small interfering rna , paclitaxel , in vivo , intracellular , in vitro , dendrimer , pancreatic cancer , peptide , conjugated system , cancer research , endosome , chemistry , rna , materials science , cancer , biochemistry , medicine , biology , microbiology and biotechnology , organic chemistry , gene , polymer
A new type of tumor‐targeted nanovehicle peptide‐conjugated PSPG ( PSPGP ) is successfully synthesized for co‐delivery of paclitaxel (PTX) and TR3 small interfering RNA (siRNA). In vitro and in vivo investigations demonstrate that the redox‐responsive PSPGP exhibit enhanced endosomal escape and intracellular degradation, which facilitate PTX and TR3 siRNA release, effectively improving the antitumor efficacy.