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Multibuilding Block Janus Synthesized by Seed‐Mediated Self‐Assembly for Enhanced Photothermal Effects and Colored Brownian Motion in an Optical Trap
Author(s) -
Sansanaphongpricha Kanokwan,
DeSantis Michael C.,
Chen Hongwei,
Cheng Wei,
Sun Kai,
Wen Bo,
Sun Duxin
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201602569
Subject(s) - photothermal therapy , janus , brownian motion , materials science , colored , micelle , nanotechnology , photothermal effect , block (permutation group theory) , nanostructure , nanoparticle , optical tweezers , chemical physics , optics , composite material , chemistry , physics , aqueous solution , geometry , mathematics , quantum mechanics
The asymmetrical features and unique properties of multibuilding block Janus nanostructures (JNSs) provide superior functions for biomedical applications. However, their production process is very challenging. This problem has hampered the progress of JNS research and the exploration of their applications. In this study, an asymmetrical multibuilding block gold/iron oxide JNS has been generated to enhance photothermal effects and display colored Brownian motion in an optical trap. JNS is formed by seed‐mediated self‐assembly of nanoparticle‐loaded thermocleavable micelles, where the hydrophobic backbones of the polymer are disrupted at high temperatures, resulting in secondary self‐assembly and structural rearrangement. The JNS significantly enhances photothermal effects compared to their homogeneous counterpart after near‐infrared (NIR) light irradiation. The asymmetrical distribution of gold and iron oxide within JNS also generates uneven thermophoretic force to display active colored Brownian rotational motion in a single‐beam gradient optical trap. These properties indicate that the asymmetrical JNS could be employed as a strong photothermal therapy mediator and a fuel‐free nanoscale Janus motor under NIR light.