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Biosynthesized Gold Nanoclusters and Iron Complexes as Scaffolds for Multimodal Cancer Bioimaging
Author(s) -
Zhao Chunqiu,
Du Tianyu,
Rehman Fawad ur,
Lai Lanmei,
Liu Xiaoli,
Jiang Xuerui,
Li Xiaoqi,
Chen Yun,
Zhang Hang,
Sun Yi,
Luo Shouhua,
Jiang Hui,
Selke Matthias,
Wang Xuemei
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201602526
Subject(s) - nanoclusters , in vivo , nanotechnology , materials science , cancer , biocompatible material , magnetic resonance imaging , metastasis , fluorescence , combinatorial chemistry , chemistry , biomedical engineering , medicine , biology , radiology , physics , microbiology and biotechnology , quantum mechanics
Cancer treatment has a far greater chance of success if the neoplasm is diagnosed before the onset of metastasis to vital organs. Hence, cancer early diagnosis is extremely important and remains a major challenge in modern therapeutics. In this contribution, facile and new method for rapid multimodal tumor bioimaging is reported by using biosynthesized iron complexes and gold nanoclusters via simple introduction of AuCl 4 − and Fe 2+ ions. The observations demonstrate that the biosynthesized Au nanoclusters may act as fluorescent and computed tomography probes for cancer bioimaging while the iron complexes behave as effective contrast agent for magnetic resonance imaging. The biosynthesized iron complexes and gold nanoclusters are found biocompatible in vitro (MTT (3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide) assay) and in vivo for all the vital organs of circulatory and excretory system. These observations raise the possibility that the biosynthesized probes may find applications in future clinical diagnosis for deep seated early neoplasms by multimodal imaging.