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Glutathione Activatable Photosensitizer‐Conjugated Pseudopolyrotaxane Nanocarriers for Photodynamic Theranostics
Author(s) -
Tong Hongxin,
Chen Yangjun,
Li Zuhong,
Li Huan,
Chen Tingting,
Jin Qiao,
Ji Jian
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601966
Subject(s) - nanocarriers , photosensitizer , photodynamic therapy , conjugated system , chemistry , chlorin , ethylene glycol , glutathione , nanotechnology , materials science , drug delivery , photochemistry , biochemistry , organic chemistry , enzyme , polymer
Photodynamic theranostics has recently been extensively explored as a promising approach for precise localization and therapy. Herein, glutathione (GSH) activatable photosensitizer (PS)‐conjugated pseudopolyrotaxane nanocarriers (α‐CD‐ss‐Ce6 NPs) are reported for enhanced photodynamic theranostics by taking advantage of the noncovalent interactions between α‐cyclodextrin (α‐CD) and poly(ethylene glycol). The designed α‐CD‐ss‐Ce6 NPs are nonactivated and stable during circulation but exhibited strong photodynamic theranostics through GSH activating after arriving at tumor site. More importantly, compared to free chlorin e6 (Ce6), such kind of pseudopolyrotaxane nanocarrier can dramatically enhance Ce6 accumulation in tumor and prolong its tumor retention time, demonstrating excellent therapeutic effects after light irradiation. Overall, the designed GSH activatable PS‐conjugated pseudopolyrotaxane nanocarrier possessing high‐performance photodynamic therapeutic efficacy together with reduced side effects offers a promising alternative for photodynamic theranostics.