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A Silver(I)‐Estrogen Nanocluster: GSH Sensitivity and Targeting Suppression on HepG2 Cell
Author(s) -
Shen DeFeng,
Wu ShanShan,
Wang RuiRui,
Zhang Qiang,
Ren ZhongJuan,
Liu Hong,
Guo HuaDong,
Gao GuangGang
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601936
Subject(s) - glutathione , cytotoxicity , fluorescence , in vitro , chemistry , reactivity (psychology) , cell culture , molecule , biophysics , biology , biochemistry , medicine , physics , alternative medicine , pathology , quantum mechanics , genetics , enzyme , organic chemistry
A structure‐determined silver nanocluster of [Ag 10 (Eth) 4 (CF 3 COO) 6 (CH 3 OH) 3 ]·3CH 3 OH (Eth = ethisterone) ( 1 ), is firstly demonstrated by self‐assembly of silver salt and ethisterone. Due to the thiophilicity of silver(I) ions, complex 1 shows reactivity with glutathione (GSH) molecules in solution and induces the fluorescence quenching behavior. Thus, complex 1 can be used as a fluorescent sensor for GSH. In consideration of the higher level of GSH in cancerous cells, complex 1 presents significant tumor suppression reactivity toward the human hepatocellular carcinoma (HepG2) cells with IC 50 value of 165 × 10 −9 m . Especially, complex 1 displays 3.4‐fold higher in vitro cytotoxicity to HepG2 cells than that of the normal CCC‐HEL‐1 cells, which makes complex 1 a potential targeting suppression agent for cancerous cells. The molecular design of complex 1 not only generates a new medicine‐silver(I) cluster family, but also opens a new avenue to the targeting anticancer organosilver(I) materials.