Premium
A Silver(I)‐Estrogen Nanocluster: GSH Sensitivity and Targeting Suppression on HepG2 Cell
Author(s) -
Shen DeFeng,
Wu ShanShan,
Wang RuiRui,
Zhang Qiang,
Ren ZhongJuan,
Liu Hong,
Guo HuaDong,
Gao GuangGang
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601936
Subject(s) - glutathione , cytotoxicity , fluorescence , in vitro , chemistry , reactivity (psychology) , cell culture , molecule , biophysics , biology , biochemistry , medicine , physics , alternative medicine , pathology , quantum mechanics , genetics , enzyme , organic chemistry
A structure‐determined silver nanocluster of [Ag 10 (Eth) 4 (CF 3 COO) 6 (CH 3 OH) 3 ]·3CH 3 OH (Eth = ethisterone) ( 1 ), is firstly demonstrated by self‐assembly of silver salt and ethisterone. Due to the thiophilicity of silver(I) ions, complex 1 shows reactivity with glutathione (GSH) molecules in solution and induces the fluorescence quenching behavior. Thus, complex 1 can be used as a fluorescent sensor for GSH. In consideration of the higher level of GSH in cancerous cells, complex 1 presents significant tumor suppression reactivity toward the human hepatocellular carcinoma (HepG2) cells with IC 50 value of 165 × 10 −9 m . Especially, complex 1 displays 3.4‐fold higher in vitro cytotoxicity to HepG2 cells than that of the normal CCC‐HEL‐1 cells, which makes complex 1 a potential targeting suppression agent for cancerous cells. The molecular design of complex 1 not only generates a new medicine‐silver(I) cluster family, but also opens a new avenue to the targeting anticancer organosilver(I) materials.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom