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DNA Binding Peptide Directed Synthesis of Continuous DNA Nanowires for Analysis of Large DNA Molecules by Scanning Electron Microscope
Author(s) -
Kim KyungIl,
Lee Seonghyun,
Jin Xuelin,
Kim Su Ji,
Jo Kyubong,
Lee Jung Heon
Publication year - 2017
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601926
Subject(s) - dna , nanowire , molecule , nanotechnology , scanning electron microscope , materials science , electron microscope , dna sequencing , biophysics , chemistry , biochemistry , biology , optics , physics , organic chemistry , composite material
Synthesis of smooth and continuous DNA nanowires , preserving the original structure of native DNA, and allowing its analysis by scanning electron microscope (SEM), is demonstrated. Gold nanoparticles densely assembled on the DNA backbone via thiol‐tagged DNA binding peptides work as seeds for metallization of DNA. This method allows whole analysis of DNA molecules with entangled 3D features.