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Bacterial Hyaluronidase Self‐Triggered Prodrug Release for Chemo‐Photothermal Synergistic Treatment of Bacterial Infection
Author(s) -
Ji Haiwei,
Dong Kai,
Yan Zhengqin,
Ding Chao,
Chen Zhaowei,
Ren Jinsong,
Qu Xiaogang
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601729
Subject(s) - photothermal therapy , nanocarriers , hyaluronidase , hyaluronic acid , prodrug , biofilm , bacteria , photothermal effect , antimicrobial , mesoporous silica , nanosheet , ascorbic acid , chemistry , drug delivery , microbiology and biotechnology , nanotechnology , materials science , biochemistry , mesoporous material , biology , organic chemistry , enzyme , food science , genetics , catalysis
A novel platform for targeted on‐demand prodrug ascorbic acid (AA) delivery is fabricated using a bacterial hyaluronidase sensitive graphene‐mesoporous silica nanosheet@hyaluronic acid‐magnetic nanoparticles as the nanocarrier to treat bacterial infections. The released AA can be converted to detrimental •OH in situ on the surface of bacteria. With the chemo‐photothermal synergistic effect, the designed antibacterial system can effectively inactivate bacteria and disperse stubborn biofilm.