Premium
G Protein‐Coupled Receptors Incorporated into Rehydrated Diblock Copolymer Vesicles Retain Functionality
Author(s) -
Gutierrez M. Gertrude,
JalaliYazdi Farzad,
Peruzzi Justin,
Riche Carson T.,
Roberts Richard W.,
Malmstadt Noah
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601540
Subject(s) - polymersome , copolymer , vesicle , g protein coupled receptor , biophysics , materials science , membrane , nanotechnology , receptor , chemistry , amphiphile , polymer , biochemistry , biology , composite material
G protein‐coupled receptor (GPCR) is incorporated into polymeric vesicles made up of diblock copolymer bilayers. Successfully incorporated GPCRs exhibit correct biased physiological orientation and respond to various ligands. After extended dehydrated storage via lyophilization and subsequent rehydration, diblock copolymer polymersomes retain their shape and incorporated GPCR retains its function.