Premium
Differential Releases of Dopamine and Neuropeptide Y from Histamine‐Stimulated PC12 Cells Detected by an Aptamer‐Modified Nanowire Transistor
Author(s) -
Banerjee Subhasree,
Hsieh YingJhu,
Liu ChiaRung,
Yeh NaiHsing,
Hung HuiHsing,
Lai YewSeng,
Chou AiChuan,
Chen YitTsong,
Pan ChienYuan
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601370
Subject(s) - nanowire , aptamer , histamine , transistor , dopamine , neuropeptide y receptor , materials science , neuropeptide , differential (mechanical device) , nanotechnology , optoelectronics , biophysics , chemistry , neuroscience , biochemistry , biology , microbiology and biotechnology , physics , electrical engineering , receptor , endocrinology , engineering , voltage , thermodynamics
Silicon nanowire field‐effect transistors modified with specific aptamers can directly detect the minute dopamine and neuropeptide Y released from cells. The binding of these molecules to the aptamers results in a conductance change of the transistor biosensor and illustrates the differential releasing mechanisms of these molecules stored in various vesicle pools.