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Tunable Lipidoid‐Telodendrimer Hybrid Nanoparticles for Intracellular Protein Delivery in Brain Tumor Treatment
Author(s) -
Wang Xu,
Bodman Alexa,
Shi Changying,
Guo Dandan,
Wang Lili,
Luo Juntao,
Hall Walter A.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601234
Subject(s) - intracellular , nanoparticle , nanotechnology , materials science , brain cancer , membrane permeability , biophysics , permeability (electromagnetism) , membrane , chemistry , cancer , biochemistry , biology , genetics
A strategy to precisely engineer lipidoid‐telodendrimer binary hybrid nanoparticles that offer enhanced cell membrane permeability for therapeutic proteins to reach the intracellular targets is established. The highly controllable biochemical and physical properties of the nanoparticles make them promising for protein‐based brain cancer treatment with the assistance of convection‐enhanced delivery.