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Recent Advances of Using Hybrid Nanocarriers in Remotely Controlled Therapeutic Delivery
Author(s) -
Li Zibiao,
Ye Enyi,
Lakshminarayanan Rajamani,
Loh Xian Jun
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601129
Subject(s) - nanocarriers , nanotechnology , drug delivery , materials science , mesoporous silica , surface modification , hybrid material , nanoparticle , controlled release , nanomedicine , micelle , mesoporous material , chemistry , aqueous solution , biochemistry , catalysis
The development of hybrid biomaterials has been attracting great attention in the design of materials for biomedicine. The nanosized level of inorganic and organic or even bioactive components can be combined into a single material by this approach, which has created entirely new advanced compositions with truly unique properties for drug delivery. The recent advances in using hybrid nanovehicles as remotely controlled therapeutic delivery carriers are summarized with respect to different nanostructures, including hybrid host–guest nanoconjugates, micelles, nanogels, core–shell nanoparticles, liposomes, mesoporous silica, and hollow nanoconstructions. In addition, the controlled release of guest molecules from these hybrid nanovehicles in response to various remote stimuli such as alternating magnetic field, near infrared, or ultrasound triggers is further summarized to introduce the different mechanisms of remotely triggered release behavior. Through proper chemical functionalization, the hybrid nanovehicle system can be further endowed with many new properties toward specific biomedical applications.