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915 nm Light‐Triggered Photodynamic Therapy and MR/CT Dual‐Modal Imaging of Tumor Based on the Nonstoichiometric Na 0.52 YbF 3.52 :Er Upconversion Nanoprobes
Author(s) -
Huang Yanan,
Xiao Qingbo,
Hu Huishan,
Zhang Kunchi,
Feng Yamin,
Li Fujin,
Wang Jian,
Ding Xianguang,
Jiang Jiang,
Li Yanfang,
Shi Liyi,
Lin Hongzhen
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601023
Subject(s) - materials science , photon upconversion , photodynamic therapy , lanthanide , luminescence , ion , optoelectronics , chemistry , organic chemistry
Lanthanide (Ln 3+ )‐doped upconversion nanoparticles (UCNPs) as a new generation of multimodal bioprobes have attracted great interest for theranostic purpose. Herein, red emitting nonstoichiometric Na 0.52 YbF 3.52 :Er UCNPs of high luminescence intensity and color purity are synthesized via a facile solvothermal method. The red UC emission from the present nanophosphors is three times more intense than the well‐known green emission from the ≈30 nm sized hexagonal‐phase NaYF 4 :Yb,Er UCNPs. By utilizing Na 0.52 YbF 3.52 :Er@SrF 2 UCNPs as multifunctional nanoplatforms, highly efficient in vitro and in vivo 915 nm light‐triggered photodynamic therapies are realized for the first time, with dramatically diminished overheating yet similar therapeutic effects in comparison to those triggered by 980 nm light. Moreover, by virtue of the high transverse relaxivity ( r 2 ) and the strong X‐ray attenuation ability of Yb 3+ ions, these UCNPs also demonstrate good performances as contrast agents for high contrast magnetic resonance and X‐ray computed tomography dual‐modal imaging. Our research shows the great potential of the red emitting Na 0.52 YbF 3.52 :Er UCNPs for multimodal imaging‐guided photodynamic therapy of tumors.