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Nanocomposite Hydrogels as Platform for Cells Growth, Proliferation, and Chemotaxis
Author(s) -
Fiorini Federica,
Prasetyanto Eko Adi,
Taraballi Francesca,
Pandolfi Laura,
Monroy Francisco,
LópezMontero Iván,
Tasciotti Ennio,
De Cola Luisa
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201601017
Subject(s) - self healing hydrogels , mesenchymal stem cell , extracellular matrix , materials science , scaffold , nanocomposite , tissue engineering , stromal cell , chemotaxis , nanotechnology , chemokine , biomedical engineering , biophysics , chemistry , microbiology and biotechnology , cancer research , medicine , polymer chemistry , biology , biochemistry , receptor
The challenge of mimicking the extracellular matrix with artificial scaffolds that are able to reduce immunoresponse is still unmet. Recent findings have shown that mesenchymal stem cells (MSC) infiltrating into the implanted scaffold have effects on the implant integration by improving the healing process. Toward this aim, a novel polyamidoamine‐based nanocomposite hydrogel is synthesized, cross‐linked with porous nanomaterials (i.e., mesoporous silica nanoparticles), able to release chemokine proteins. A comprehensive viscoelasticity study confirms that the hydrogel provides optimal structural support for MSC infiltration and proliferation. The efficiency of this hydrogel, containing the chemoattractant stromal cell‐derived factor 1α (SDF‐1α), in promoting MSC migration in vitro is demonstrated. Finally, subcutaneous implantation of SDF‐1α‐releasing hydrogels in mice results in a modulation of the inflammatory reaction. Overall, the proposed SDF‐1α‐nanocomposite hydrogel proves to have potential for applications in tissue engineering.