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Embedding Raman Tags between Au Nanostar@Nanoshell for Multiplex Immunosensing
Author(s) -
Yang Ting,
Jiang Jiang
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201600532
Subject(s) - nanoshell , multiplex , nanotechnology , raman scattering , raman spectroscopy , colloidal gold , biosensor , nanoparticle , computer science , materials science , chemistry , physics , bioinformatics , optics , biology
Novel Raman tags with various reporter molecules embedded in between gold nanostar (AuNS) and gold nanoshell are developed, showing significantly enhanced surface‐enhanced Raman scattering intensity compared to gold nanoparticle‐based composites. Immunoassay using these AuNS@tag@shell structures is highly specific with sensitivity down to 0.1 pg mL −1 , and is capable of multiplex detection, making them highly promising for biosensing applications.