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Lanthanide Hydroxide Nanoparticles Induce Angiogenesis via ROS‐Sensitive Signaling
Author(s) -
Zhao Haishan,
Osborne Olivia J.,
Lin Sijie,
Ji Zhaoxia,
Damoiseux Robert,
Wang Yuqiang,
Nel André E.,
Lin Shuo
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201600291
Subject(s) - europium , lanthanide , angiogenesis , nanoparticle , materials science , nanotechnology , terbium , nanorod , chemistry , biophysics , organic chemistry , biology , ion , cancer research
Recent studies suggest that the nanorods consisting of europium hydroxide could promote angiogenesis. In this study, it is sought to determine if additional types of nanoparticles are capable of enhancing angiogenesis and in addition, understand the underlying mechanisms. For this reason, a method is employed that combines a high throughput in vitro cell based screen coupled with an in vivo validation using vascular specific green fluorescent protein reporter transgenic zebrafish for examining proangiogenesis activity. After screening multiple types of nanoparticles, it is discovered that four of them, Eu III (OH) 3 rods (Eu rods), Eu III (OH) 3 spheres (Eu spheres), Tb III (OH) 3 rods (Tb rods), and Tb III (OH) 3 spheres (Tb spheres), are the most effective in promoting angiogenesis. It is also showed that ionic forms of europium nitrate [Eu(NO 3 ) 3 ] (Eu) and terbium nitrate [Tb(NO 3 ) 3 ] (Tb), the two lanthanide elements for these four nanoparticles, are also capable of enhancing angiogenesis. However, this effect is further enhanced by nanoparticle synthesis. Finally, it is demonstrated that reactive oxygen species H 2 O 2 is a key factor in the process of proangiogenesis by lanthanide elemental nanoparticles.