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Flexible Octopus‐Shaped Hydrogel Particles for Specific Cell Capture
Author(s) -
Chen Lynna,
An Harry Z.,
Haghgooie Ramin,
Shank Aaron T.,
Martel Joseph M.,
Toner Mehmet,
Doyle Patrick S.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201600163
Subject(s) - particle (ecology) , nanotechnology , computer science , materials science , adhesion , service (business) , composite material , geology , oceanography , economy , economics
Multiarm hydrogel microparticles with varying geometry are fabricated to specifically capture cells expressing epithelial cell adhesion molecule. Results show that particle shape influences cell‐capture efficiency due to differences in surface area, hydrodynamic effects, and steric constraints. These findings can lead to improved particle design for cell separation and diagnostic applications.