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Self‐Assembly: Host–Guest Interaction‐Mediated Construction of Hydrogels and Nanovesicles for Drug Delivery (Small 44/2015)
Author(s) -
Xu XingDong,
Li Xin,
Chen Hongzhong,
Qu Qiuyu,
Zhao Lingzhi,
Ågren Hans,
Zhao Yanli
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570263
Subject(s) - nanocarriers , amphiphile , cytotoxicity , drug delivery , doxorubicin , self healing hydrogels , drug , nanotechnology , chemistry , targeted drug delivery , derivative (finance) , anticancer drug , self assembly , materials science , biophysics , organic chemistry , copolymer , polymer , biochemistry , pharmacology , in vitro , medicine , biology , surgery , chemotherapy , economics , financial economics
A 1,8‐naphthalimide derivative that forms a stable hydrogel with very low critical gelation concentration is reported by Y. Zhao and co‐workers. By taking advantage of the host–guest interaction, the complexation of this compound with cucurbit[8]uril leads to the formation of nanovesicles on page 5901. A cytotoxicity assay with cancer cells confirms that doxorubicin‐loaded hydrogel and nanovesicles are effectively endocytosed by cancer cells, showing therapeutic effects. This work provides a strategy in the development of multiple drug nanocarriers from amphiphilic assemblies.