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Helium Ion Microscopy: Helium Ion Microscopy Visualizes Lipid Nanodomains in Mammalian Cells (Small 43/2015)
Author(s) -
Schürmann Matthias,
Frese Natalie,
Beyer André,
Heimann Peter,
Widera Darius,
Mönkemöller Viola,
Huser Thomas,
Kaltschmidt Barbara,
Kaltschmidt Christian,
Gölzhäuser Armin
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570262
Subject(s) - microscope , microscopy , helium , materials science , field ion microscope , optical microscope , resolution (logic) , electron microscope , ion , membrane , nanotechnology , scanning electron microscope , chemistry , optics , physics , biochemistry , organic chemistry , artificial intelligence , computer science , composite material
On page 5781, B. Kaltschmidt, C. Kaltschmidt, A. Gölzhäuser, and co‐workers show how helium ion microscopy is capable of imaging biological specimens without any conductive coating, and it allows the identification of nanodomains in the ultrastructure of membranes with 1.5 nm resolution. The image here shows two mouse neurons. One neuron is imaged with an optical microscope, the other neuron is imaged with the helium ion microscope. The helium ion microscope image includes a high‐resolution inset, which depicts membrane nanodomains.