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Magnetic Separation: Optimization of Pathogen Capture in Flowing Fluids with Magnetic Nanoparticles (Small 42/2015)
Author(s) -
Kang Joo H.,
Um Eujin,
Diaz Alexander,
Driscoll Harry,
Rodas Melissa J.,
Domansky Karel,
Watters Alexander L.,
Super Michael,
Stone Howard A.,
Ingber Donald E.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570253
Subject(s) - magnetic nanoparticles , magnetic separation , materials science , nanoparticle , pathogen , magnetic bead , separation (statistics) , bead , nanotechnology , chemistry , chromatography , microbiology and biotechnology , computer science , biology , composite material , machine learning , metallurgy
D. E. Ingber and co‐workers illustrate the capture and removal of bacterial cells from flowing blood by binding them to different‐sized magnetic particles that are pulled by magnetic fields. On page 5657, they explain how the optimal size of these magnetic nanoparticles for continuous magnetophoretic pathogen separation is determined. A new theoretical model describing pathogen binding and separation efficiencies is described, and shown to accurately predict the optimal size to promote bead capture in experimental trials.