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Carbon Nanospheres: Tunable Luminescent Carbon Nanospheres with Well‐Defined Nanoscale Chemistry for Synchronized Imaging and Therapy (Small 36/2015)
Author(s) -
Mukherjee Prabuddha,
Misra Santosh K.,
Gryka Mark C.,
Chang HueiHuei,
Tiwari Saumya,
Wilson William L.,
Scott John W.,
Bhargava Rohit,
Pan Dipanjan
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570224
Subject(s) - nanoparticle , luminescence , nanoscopic scale , carbon fibers , materials science , polymer , drug delivery , nanotechnology , fluorescence , carbon nanoparticles , coating , chemical engineering , optoelectronics , optics , physics , engineering , composite number , composite material
Drug (PTX)‐loaded luminescent carbon nanoparticles (LCNs) are passivated with a thermoresponsive polymer (PNIPAM) inside melanoma cells. On page 4691, R. Bhargava, D. Pan, and co‐workers acquire such images using confocal fluorescence techniques. A representative cartoon of the nanoparticles is shown in black, where the white and the green shells represent the anti‐cancer drug (PTX: molecular structure shown) and the PNIPAM coating, respectively. The cells, upon internalizing the particles under physiological conditions, trigger the delivery of drugs contained in them.