Premium
Drug Delivery: Tumor‐Triggered Controlled Drug Release from Electrospun Fibers Using Inorganic Caps for Inhibiting Cancer Relapse (Small 34/2015)
Author(s) -
Zhao Xin,
Yuan Ziming,
Yildirimer Lara,
Zhao Jingwen,
Lin Zhi Yuan William,
Cao Zhi,
Pan Guoqing,
Cui Wenguo
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570205
Subject(s) - drug , drug delivery , penetration (warfare) , cancer , nanotechnology , controlled release , materials science , chemistry , pharmacology , medicine , operations research , engineering
A smart, tumor‐trigged, controlled drug release using inorganic “caps” with CO 3 2− functional groups in electrospun fibers is reported by W. Cui and co‐workers on page 4284 to inhibit cancer relapse. When the drug‐loaded intelligent electrospun fibers encounter pathological acidic environments, the inorganic gates will react with the acids and produce CO 2 gas, which enables water penetration into the core of the fibers to induce rapid drug release.