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Drug Delivery: Zn 2+ ‐Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates (Small 31/2015)
Author(s) -
Tan LiLi,
Li Haiwei,
Zhou Yue,
Zhang Yuanyuan,
Feng Xiao,
Wang Bo,
Yang YingWei
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570190
Subject(s) - nanomedicine , drug delivery , nanotechnology , supramolecular chemistry , drug , materials science , zirconium , biocompatible material , targeted drug delivery , nanoparticle , chemistry , pharmacology , biomedical engineering , medicine , organic chemistry , crystal structure , metallurgy
Encouraged by recent advances in materials science and nanomedicine, on page 3807 Y.‐W. Yang and co‐workers first applied benign activation mechanisms to targeted drug‐release systems based on monodisperse, biofriendly zirconium nanoMOFs with pillarene‐based stimuli‐responsive supramolecular switches as nanovalves, aiming at targeted CNS disease therapy by combining physical (thermal heating) and natural biochemical treatments (Zn 2+ ions, abundant in synaptic vesicles). This nanoscale‐targeted smart drug‐delivery system will prove to be a new generation of drug‐delivery systems especially for CNS disease therapy in the near future.