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Uptake: Factors Ruling the Uptake of Silica Nanoparticles by Mesenchymal Stem Cells: Agglomeration Versus Dispersions, Absence Versus Presence of Serum Proteins (Small 24/2015)
Author(s) -
Catalano Federico,
Accomasso Lisa,
Alberto Gabriele,
Gallina Clara,
Raimondo Stefania,
Geuna Stefano,
Giachino Claudia,
Martra Gianmario
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570140
Subject(s) - nanoparticle , mesenchymal stem cell , agglomerate , economies of agglomeration , nanometre , biophysics , chemical engineering , chemistry , materials science , microbiology and biotechnology , nanotechnology , biology , engineering
The effect of the presence or absence of serum proteins in the culture medium on the uptake of silica nanoparticles by human mesenchymal stem cells are discussed by G. Martra and co‐workers on page 2919. In serum‐free conditions, micrometric agglomerates of silica nanoparticles are formed, which are quickly taken up by cells. Conversely, in the presence of serum proteins, nanoparticle agglomerates become smaller (hundreds of nanometers) and are covered by a protein corona. Nevertheless, their uptake by cells is significantly delayed.