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Antiviral Agents: Correlation between Membrane Partitioning and Functional Activity in a Single Lipid Vesicle Assay Establishes Design Guidelines for Antiviral Peptides (Small 20/2015)
Author(s) -
Jackman Joshua A.,
Saravanan Rathi,
Zhang Yibang,
Tabaei Seyed R.,
Cho NamJoon
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570117
Subject(s) - vesicle , lipid vesicle , vesicle fusion , membrane , chemistry , biophysics , lipid bilayer , peptide , nanotechnology , biochemistry , materials science , biology , synaptic vesicle
A nanotechnology platform for highly parallel measurements is presented by N.‐J. Cho and co‐workers which monitors the interaction between membrane‐active antiviral peptides and individual lipid vesicles. On page 2372, each vesicle is tethered to a passivated glass surface for highly specific detection. When the peptide forms a pore in the vesicle, fluorescent dye is released from inside the vesicle and the intensity change per vesicle can be followed in real time. Quantitative measurement capabilities enable comparison of various agents and are useful for drug development research.