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Immunoengineering: Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T‐Cell Activation (Small 13/2015)
Author(s) -
Meyer Randall A.,
Sunshine Joel C.,
Perica Karlo,
Kosmides Alyssa K.,
Aje Kent,
Schneck Jonathan P.,
Green Jordan J.
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570077
Subject(s) - antigen , artificial cell , nanotechnology , microbiology and biotechnology , materials science , biophysics , chemistry , biology , membrane , immunology , biochemistry
Nonspherical ellipsoidal nanodimensional artificial antigen‐presenting cells (aAPCs) are fabricated by J. J. Green and co‐workers and on page 1519 they are shown to have superior T‐Cell activation and pharmacokinetic properties compared to equivalent spherical nanodimensional aAPCs. Shown on the cover are transmission electron microscopy images of the ellipsoidal nanoparticles interacting with a computer generated T‐Cell membrane as nano aAPCs. Due to their larger radius of curvature, ellipsoidal nano aAPCs are more effective at biomimicry of natural APCs for antigen‐specific T‐Cell activation.