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Biomaterials: Efficient Encapsulation of Fe 3 O 4 Nanoparticles into Genetically Engineered Hepatitis B Core Virus‐Like Particles Through a Specific Interaction for Potential Bioapplications (Small 9‐10/2015)
Author(s) -
Shen Lihua,
Zhou Jun,
Wang Yixiao,
Kang Ning,
Ke Xuebin,
Bi Shengli,
Ren Lei
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570056
Subject(s) - nitrilotriacetic acid , nanoparticle , nanotechnology , materials science , magnetic nanoparticles , nanomedicine , virus like particle , chelation , chemistry , biochemistry , recombinant dna , metallurgy , gene
A method to encapsulate magnetic nanoparticles into His‐tagged virus‐like particles (VLPs) is developed by L. Ren and co‐workers on page 1190. It is the first report using the affinity of histidine tags for the nickel‐nitrilotriacetic acid chelate to trigger encapsulation of nanoparticles by VLPs. This makes it possible to integrate a wide range of starting nanoparticles into fundamentally different kinds of viral coating proteins or other nonenveloped viruses for application in cancer nanotechnology and medicine.