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CNT Biosafety: Multiwall Carbon Nanotubes Directly Promote Fibroblast–Myofibroblast and Epithelial–Mesenchymal Transitions through the Activation of the TGF‐β/Smad Signaling Pathway (Small 4/2015)
Author(s) -
Wang Peng,
Wang Yue,
Nie Xin,
Braïni Céline,
Bai Ru,
Chen Chunying
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201570019
Subject(s) - myofibroblast , mesenchymal stem cell , fibroblast , epithelial–mesenchymal transition , pulmonary fibrosis , microbiology and biotechnology , smad , transforming growth factor , fibrosis , signal transduction , cardiac fibrosis , chemistry , cancer research , materials science , medicine , downregulation and upregulation , biology , in vitro , pathology , biochemistry , gene
The underlying mechanisms demonstrated by C. Chen and co‐workers on page 446 show how multiwalled carbon nanotubes (MWCNTs) induce granuloma formation and fibrotic responses in vivo. MWCNT exposure can promote a fibroblast‐to‐myofibroblast conversion and the epithelial‐mesenchymal transition (EMT) through the activation of the TGF‐ß/Smad signaling pathway. Both of the cell transitions may play important roles in MWCNT‐induced pulmonary fibrosis.