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Adenosine‐Activated Nanochannels Inspired by G‐Protein‐Coupled Receptors
Author(s) -
Li Pei,
Kong XiangYu,
Xie Ganhua,
Xiao Kai,
Zhang Zhen,
Wen Liping,
Jiang Lei
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201503863
Subject(s) - nanodevice , aptamer , adenosine , nanotechnology , computer science , biosensor , encoder , chemistry , computational biology , materials science , biology , biochemistry , microbiology and biotechnology , operating system
A bioinspired adenosine activated nanodevice is demonstrated in which the conformations of the designed aptamer change and cause signal transmission according to the emergence of adenosine. This bioinspired system exhibits very high response ratios (activated/nonactivated ratio up to 614) and excellent stability and reversibility, and shows promising applications in the fields of biosensors, pharmaceutica, and healthcare systems.