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Gold‐Quantum Dot Core–Satellite Assemblies for Lighting Up MicroRNA In Vitro and In Vivo
Author(s) -
Zhao Xueli,
Xu Liguang,
Sun Maozhong,
Ma Wei,
Wu Xiaoling,
Kuang Hua,
Wang Libing,
Xu Chuanlai
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201503629
Subject(s) - quantum dot , in vivo , satellite , microrna , core (optical fiber) , fluorescence , dna , in vitro , nanotechnology , biology , materials science , physics , gene , genetics , optics , astronomy
A high yield DNA‐driven gold‐quantum dot core–satellite is developed for miRNA detection in vitro and vivo. In the presence of the target miRNA, the DNA hairpin between core and satellite is ruined, resulting in the recovery of fluorescence. The limit of detection for miRNA‐21 detection in living cells reaches 296 copies per cell.