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Mitochondrial Delivery of Therapeutic Agents by Amphiphilic DNA Nanocarriers
Author(s) -
Chan Miu Shan,
Tam Dick Yan,
Dai Ziwen,
Liu Ling Sum,
Ho Jonathan WengThim,
Chan Man Lee,
Xu Di,
Wong Man Shing,
Tin Chung,
Lo Pik Kwan
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201503051
Subject(s) - nanocarriers , nanocages , doxorubicin , cytotoxicity , drug delivery , organelle , mitochondrion , apoptosis , chemistry , liposome , amphiphile , drug carrier , dna , microbiology and biotechnology , pharmacology , biochemistry , biology , chemotherapy , in vitro , polymer , organic chemistry , copolymer , genetics , catalysis
The first example of mitochondrial delivery of the anticancer drug doxorubicin (Dox) is presented by lipid‐functionalized DNA nanocages (LNCs). Dox localized in mitochondria induces significant cytotoxicity and cellular apoptosis in MCF‐7 compared with Dox localized in lysosomes. These results suggest that LNC has the potential to be an outstanding tool in the treatment of specific organelle‐related diseases such as cancers.