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Submicrometer‐Sized Thermometer Particles Exploiting Selective Nucleic Acid Stability
Author(s) -
Puddu Michela,
Mikutis Gediminas,
Stark Wendelin J.,
Grass Robert N.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201502883
Subject(s) - thermometer , nucleic acid , computer science , stability (learning theory) , nanotechnology , class (philosophy) , thermal stability , protocol (science) , process engineering , materials science , chemistry , artificial intelligence , physics , engineering , machine learning , biochemistry , organic chemistry , quantum mechanics , medicine , alternative medicine , pathology
Encapsulated nucleic acid selective damage quantification by real‐time polymerase chain reaction is used as sensing mechanism to build a novel class of submicrometer size thermometer. Thanks to the high thermal and chemical stability, and the capability of storing the read accumulated thermal history, the sensor overcomes some of current limitations in small scale thermometry.