L ‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles | Zendy

McDonagh Birgitte Hjelmeland | Zendy; Singh Gurvinder | Zendy; Hak Sjoerd | Zendy; Bandyopadhyay Sulalit | Zendy; Augestad Ingrid Lovise | Zendy; Peddis Davide | Zendy; Sandvig Ioanna | Zendy; Sandvig Axel | Zendy; Glomm Wilhelm Robert | Zendy

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L ‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles

Author(s) -

McDonagh Birgitte Hjelmeland,

Singh Gurvinder,

Hak Sjoerd,

Bandyopadhyay Sulalit,

Augestad Ingrid Lovise,

Peddis Davide,

Sandvig Ioanna,

Sandvig Axel,

Glomm Wilhelm Robert

Publication year - 2016

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201502545

Subject(s) - drug delivery , nanoparticle , manganese oxide , drug , contrast (vision) , materials science , dual (grammatical number) , chemistry , manganese , nanotechnology , biomedical engineering , pharmacology , medicine , metallurgy , computer science , artificial intelligence , art , literature

Manganese oxide nanoparticles (MONPs) are capable of time‐dependent magnetic resonance imaging contrast switching as well as releasing a surface‐bound drug. MONPs give T2/T2 * contrast, but dissolve and release T1‐active Mn 2+ and L ‐3,4‐dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.

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