Premium
L ‐DOPA‐Coated Manganese Oxide Nanoparticles as Dual MRI Contrast Agents and Drug‐Delivery Vehicles
Author(s) -
McDonagh Birgitte Hjelmeland,
Singh Gurvinder,
Hak Sjoerd,
Bandyopadhyay Sulalit,
Augestad Ingrid Lovise,
Peddis Davide,
Sandvig Ioanna,
Sandvig Axel,
Glomm Wilhelm Robert
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201502545
Subject(s) - drug delivery , nanoparticle , manganese oxide , drug , contrast (vision) , materials science , dual (grammatical number) , chemistry , manganese , nanotechnology , biomedical engineering , pharmacology , medicine , metallurgy , computer science , artificial intelligence , art , literature
Manganese oxide nanoparticles (MONPs) are capable of time‐dependent magnetic resonance imaging contrast switching as well as releasing a surface‐bound drug. MONPs give T2/T2 * contrast, but dissolve and release T1‐active Mn 2+ and L ‐3,4‐dihydroxyphenylalanine. Complementary images are acquired with a single contrast agent, and applications toward Parkinson's disease are suggested.