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Programmable Downregulation of Enzyme Activity Using a Fever and NIR‐Responsive Molecularly Imprinted Nanocomposite
Author(s) -
Zhang Zhijun,
Wang Zhenzhen,
Wang Faming,
Ren Jinsong,
Qu Xiaogang
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201502071
Subject(s) - downregulation and upregulation , nanocomposite , enzyme , computer science , chemistry , nanotechnology , materials science , biochemistry , gene
A fever and NIR‐responsive molecularly imprinted nanocomposite is designed for programmable downregulation of enzyme activity. The target enzyme can be captured specifically and its activity can be downregulated only when body temperature increases abnormally. Upon NIR irradiation, the temperature of the destination region can increase accordingly inducing a further decrease in the enzyme activity.