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Photonic Crystal Hydrogel Enhanced Plasmonic Staining for Multiplexed Protein Analysis
Author(s) -
Mu Zhongde,
Zhao Xiangwei,
Huang Yin,
Lu Meng,
Gu Zhongze
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201501829
Subject(s) - plasmon , materials science , raman spectroscopy , photonic crystal , surface enhanced raman spectroscopy , biosensor , nanoparticle , nanostructure , nanotechnology , photonics , optoelectronics , optics , raman scattering , physics
Plasmonic nanoparticles are commonly used as optical transducers in sensing applications. The optical signals resulting from the interaction of analytes and plamsonic nanoparticles are influenced by surrounding physical structures where the nanoparticles are located. This paper proposes inverse opal photonic crystal hydrogel as 3D structure to improve Raman signals from plasmonic staining. By hybridization of the plasmonic nanoparticles and photonic crystal, surface‐enhanced Raman spectroscopy (SERS) analysis of multiplexed protein is realized. It benefits the Raman analysis by providing high‐density “hot spots” in 3D and extra enhancement of local electromagnetic field at the band edge of PhC with periodic refractive index distribution. The strong interaction of light and the hybrid 3D nanostructure offers new insights into plasmonic nanoparticle applications and biosensor design.