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A pH‐Responsive Drug‐Delivery Platform Based on Glycol Chitosan–Coated Liposomes
Author(s) -
Yan Lesan,
Crayton Samuel H.,
Thawani Jayesh P.,
Amirshaghaghi Ahmad,
Tsourkas Andrew,
Cheng Zhiliang
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201501412
Subject(s) - liposome , chitosan , drug delivery , doxorubicin , chemistry , nanotechnology , computer science , combinatorial chemistry , materials science , biochemistry , medicine , chemotherapy , surgery
pH‐responsive liposomes are prepared by conjugating glycol chitosan (GC) to the outer lipid membrane. This functionalization allows the liposomes to transition from a negative charge at physiologic pH to a positive charge in the acidic extracellular tumor microenvironment. Upon obtaining a positive charge, the GC‐liposomes loaded with doxorubicin exhibited enhanced cellular uptake and improved anticancer efficacy.