mRNA‐Producing Pseudo‐nucleus System | Zendy

Shin Seung Won | Zendy; Park Kyung Soo | Zendy; Shin Woo Jung | Zendy; Um Soong Ho | Zendy

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mRNA‐Producing Pseudo‐nucleus System

Author(s) -

Shin Seung Won,

Park Kyung Soo,

Shin Woo Jung,

Um Soong Ho

Publication year - 2015

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201501334

Subject(s) - nucleus , messenger rna , dna , cytosol , transcription (linguistics) , microbiology and biotechnology , gene , translation (biology) , delivery system , gene expression , chemistry , biophysics , biology , biochemistry , enzyme , linguistics , philosophy , pharmacology

A pseudo‐eukaryotic nucleus (PEN) system consisting of a gene‐containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene‐containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57‐fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.

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