Premium
mRNA‐Producing Pseudo‐nucleus System
Author(s) -
Shin Seung Won,
Park Kyung Soo,
Shin Woo Jung,
Um Soong Ho
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201501334
Subject(s) - nucleus , messenger rna , dna , cytosol , transcription (linguistics) , microbiology and biotechnology , gene , translation (biology) , delivery system , gene expression , chemistry , biophysics , biology , biochemistry , enzyme , linguistics , philosophy , pharmacology
A pseudo‐eukaryotic nucleus (PEN) system consisting of a gene‐containing DNA hydrogel encapsulated in a liposome is fabricated. Owing to the structural characteristics of gene‐containing DNA hydrogel, mRNA transcription efficiency is promoted 2.57‐fold. Through the use of PEN as a platform for mRNA delivery to the cytosol, prolonged protein translation is achieved.