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A Self‐Assembled DNA Origami‐Gold Nanorod Complex for Cancer Theranostics
Author(s) -
Jiang Qiao,
Shi Yuefeng,
Zhang Qian,
Li Na,
Zhan Pengfei,
Song Linlin,
Dai Luru,
Tian Jie,
Du Yang,
Cheng Zhen,
Ding Baoquan
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201501266
Subject(s) - photothermal therapy , nanorod , dna origami , materials science , nanotechnology , in vivo , cancer cell , two photon excitation microscopy , irradiation , cancer , biophysics , optics , biology , nanostructure , fluorescence , genetics , microbiology and biotechnology , physics , nuclear physics
A self‐assembled DNA origami (DO)‐gold nanorod (GNR) complex, which is a dual‐functional nanotheranostics constructed by decorating GNRs onto the surface of DNA origami, is demonstrated. After 24 h incubation of two structured DO‐GNR complexes with human MCF7 breast cancer cells, significant enhancement of cell uptake is achieved compared to bare GNRs by two‐photon luminescence imaging. Particularly, the triangle shaped DO‐GNR complex exhibits optimal cellular accumulation. Compared to GNRs, improved photothermolysis against tumor cells is accomplished for the triangle DO‐GNR complex by two‐photon laser or NIR laser irradiation. Moreover, the DO‐GNR complex exhibits enhanced antitumor efficacy compared with bare GNRs in nude mice bearing breast tumor xenografts. The results demonstrate that the DO‐GNR complex can achieve optimal two‐photon cell imaging and photothermal effect, suggesting a promising candidate for cancer diagnosis and therapy both in vitro and in vivo.