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Critical Points in Tumorigenesis: A Carcinogen‐Initiated Phase Transition Analyzed via Single‐Cell Proteomics
Author(s) -
Poovathingal Suresh Kumar,
KravchenkoBalasha Nataly,
Shin Young Shik,
Levine Raphael David,
Heath James R.
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201501178
Subject(s) - carcinogenesis , phase transition , cell , proteomics , transition (genetics) , single cell analysis , materials science , chemistry , biophysics , biology , physics , thermodynamics , biochemistry , gene
A kinetic, single‐cell proteomic study of chemically induced carcinogenesis is interpreted by treating the single‐cell data as fluctuations of an open system transitioning between different steady states. In analogy to a first‐order transition, phase coexistence and the loss of degrees of freedom are observed. The transition is detected well before the appearance of the traditional biomarker of the carcinogenic transformation.