Premium
On‐Chip Magnetic Platform for Single‐Particle Manipulation with Integrated Electrical Feedback
Author(s) -
Monticelli Marco,
Torti Andrea,
Cantoni Matteo,
Petti Daniela,
Albisetti Edoardo,
Manzin Alessandra,
Guerriero Erica,
Sordan Roman,
Gervasoni Giacomo,
Carminati Marco,
Ferrari Giorgio,
Sampietro Marco,
Bertacco Riccardo
Publication year - 2016
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201500916
Subject(s) - magnetic field , materials science , displacement (psychology) , particle (ecology) , magnetic nanoparticles , magnetic particle inspection , nanotechnology , suspension (topology) , magnetic domain , magnetoresistance , physics , nanoparticle , magnetization , psychology , oceanography , mathematics , quantum mechanics , homotopy , pure mathematics , psychotherapist , geology
Methods for the manipulation of single magnetic particles have become very interesting, in particular for in vitro biological studies. Most of these studies require an external microscope to provide the operator with feedback for controlling the particle motion, thus preventing the use of magnetic particles in high‐throughput experiments. In this paper, a simple and compact system with integrated electrical feedback is presented, implementing in the very same device both the manipulation and detection of the transit of single particles. The proposed platform is based on zig‐zag shaped magnetic nanostructures, where transverse magnetic domain walls are pinned at the corners and attract magnetic particles in suspension. By applying suitable external magnetic fields, the domain walls move to the nearest corner, thus causing the step by step displacement of the particles along the nanostructure. The very same structure is also employed for detecting the bead transit. Indeed, the presence of the magnetic particle in suspension over the domain wall affects the depinning field required for its displacement. This characteristic field can be monitored through anisotropic magnetoresistance measurements, thus implementing an integrated electrical feedback of the bead transit. In particular, the individual manipulation and detection of single 1‐μm sized beads is demonstrated.