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Tackling Cell Transplantation Anoikis: An Injectable, Shape Memory Cryogel Microcarrier Platform Material for Stem Cell and Neuronal Cell Growth
Author(s) -
Newland Ben,
Welzel Petra B.,
Newland Heike,
Renneberg Claudia,
Kolar Petr,
Tsurkan Mikhail,
Rosser Anne,
Freudenberg Uwe,
Werner Carsten
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201500898
Subject(s) - microcarrier , transplantation , stem cell , anoikis , cell , computer science , materials science , chemistry , microbiology and biotechnology , biology , medicine , apoptosis , surgery , biochemistry , programmed cell death
Highly macroporous semisynthetic cryogel microcarriers can be synthesized for culturing stem cells and neuronal type cells. Growth factors loaded to heparin‐containing microcarriers show near zero‐order release kinetics and cell‐loaded microcarriers can be injected through a fine gauge cannula without negative effect on the cells. These carriers can be applied for cell transplantation applications.