Development of a High‐Throughput Functional Screen Using Nanowell‐Assisted Cell Patterning | Zendy

Ozkumur Ayca Yalcin | Zendy; Goods Brittany A. | Zendy; Love J. Christopher | Zendy

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Development of a High‐Throughput Functional Screen Using Nanowell‐Assisted Cell Patterning

Author(s) -

Ozkumur Ayca Yalcin,

Goods Brittany A.,

Love J. Christopher

Publication year - 2015

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201500674

Subject(s) - scalability , computer science , throughput , computational biology , human immunodeficiency virus (hiv) , nanotechnology , information retrieval , biology , materials science , database , telecommunications , virology , wireless

Living‐cell‐based screens can facilitate lead discovery of functional therapeutics of interest. A versatile and scalable method is reported that uses dense arrays of nanowells for imparting defined patterns on monolayers of cells. It is shown that this approach can coordinate a multi‐component biological assay by designing and implementing a high‐throughput, functional nanoliter‐scale neutralization assay to identify neutralizing antibodies against HIV.

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