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Zn 2+ ‐Triggered Drug Release from Biocompatible Zirconium MOFs Equipped with Supramolecular Gates
Author(s) -
Tan LiLi,
Li Haiwei,
Zhou Yue,
Zhang Yuanyuan,
Feng Xiao,
Wang Bo,
Yang YingWei
Publication year - 2015
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201500155
Subject(s) - biocompatibility , drug delivery , nanotechnology , zirconium , drug , materials science , supramolecular chemistry , controlled release , biocompatible material , metal organic framework , chemistry , biomedical engineering , pharmacology , organic chemistry , medicine , adsorption , crystal structure , metallurgy
A new theranostic nanoplatform, comprising of monodisperse zirconium metal‐organic frameworks (MOFs) as drug carriers and carboxylatopillar[5]arene‐based supramolecular switches as gating entities, is constructed, and controlled drug release triggered by bio‐friendly Zn 2+ ions (abundant in synaptic vesicles) and auxiliary thermal stimulus is realized. This on‐command drug delivery system exhibits large pore sizes for drug encapsulation, excellent biodegradability and biocompatibility, extremely low cytotoxicity and premature drug release, and superior dual‐stimuli responsiveness, opening a new avenue in targeted drug delivery and controlled release of therapeutic agents, especially in the treatment of central nervous system diseases.