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Protein Therapy: Synthesis of Silica Vesicles with Controlled Entrance Size for High Loading, Sustained Release, and Cellular Delivery of Therapeutical Proteins (Small 24/2014)
Author(s) -
Zhang Jun,
Karmakar Surajit,
Yu Meihua,
Mitter Neena,
Zou Jin,
Yu Chengzhong
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470153
Subject(s) - vesicle , biomolecule , nanotechnology , materials science , biophysics , particle size , controlled release , chemistry , biochemistry , biology , membrane
C. Yu and co‐workers demonstrate silica vesicles with fine control over the entrance size in the siliceous walls (<3.9–34 nm). On page 5068, the entrance size is shown to be crucial for the loading and releasing of biomolecules. Silica vesicles with an optimal entrance size exhibit high loading capacity, sustained release, and superior delivery efficiency of therapeutical proteins into cells, showing promising potential for biological and biomedical applications.