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Cancer Therapy: Folic Acid Functionalized Surface Highlights 5‐Methylcytosine‐Genomic Content within Circulating Tumor Cells (Small 21/2014)
Author(s) -
Malara Natalia,
Coluccio Maria Laura,
Limongi Tania,
Asande Monica,
Trunzo Valentina,
Cojoc Gheorghe,
Raso Cinzia,
Candeloro Patrizio,
Perozziello Gerardo,
Raimondo Raffaella,
De Vitis Stefania,
Roveda Laura,
Renne Maria,
Prati Ubaldo,
Mollace Vincenzo,
Di Fabrizio Enzo
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470135
Subject(s) - folate receptor , folic acid , methylation , cancer , surface modification , circulating tumor cell , cancer research , materials science , pathology , cancer cell , biomedical engineering , nanotechnology , chemistry , medicine , biochemistry , dna , metastasis
A folic acid (FA)‐functionalized surface, able to selectively entrap circulating tumor cell (CTC)‐expressing folic receptors, is developed by E. Di Fabrizio and co‐workers on page 4324. Since FA represents a good transducer highlighting the CTC global 5‐methylcytosine content, this functionalized surface represents an important tool to profile cellular methylation changes in tumor monitoring strategies. The image shows CTCs under a scanning electron microscope after fixation and metallization. Image credit: M. Orlando, R. Ruffilli, and V. Shalabaeva.