Stem Cells: Hepatic Differentiation of Human Embryonic Stem Cells as Microscaled Multilayered Colonies Leading to Enhanced Homogeneity and Maturation (Small 21/2014) | Zendy

Yao Rui | Zendy; Wang Jingyu | Zendy; Li Xiaokang | Zendy; Jung Jung Da | Zendy; Qi Hao | Zendy; Kee Keh Kooi | Zendy; Du Yanan | Zendy

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Stem Cells: Hepatic Differentiation of Human Embryonic Stem Cells as Microscaled Multilayered Colonies Leading to Enhanced Homogeneity and Maturation (Small 21/2014)

Author(s) -

Yao Rui,

Wang Jingyu,

Li Xiaokang,

Jung Jung Da,

Qi Hao,

Kee Keh Kooi,

Du Yanan

Publication year - 2014

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.201470133

Subject(s) - embryonic stem cell , regenerative medicine , induced pluripotent stem cell , hepatocyte , microbiology and biotechnology , stem cell , biology , directed differentiation , cellular differentiation , tissue engineering , nanotechnology , in vitro , materials science , biochemistry , gene , genetics

A versatile methodology for the derivation of 3D human hepatocyte aggregates with mature phenotype, homogenous morphology, and enhanced hepatic functions is introduced on page 4311 by Y. Du and co‐workers. The continuous hepatic differentiation of pluripotent hESCs is realized in 3D multilayered microtissue format by a versatile off‐the‐shelf microstencil array. The 3D configuration for hepatic differentiation of hESCs represents a significant step toward the efficient generation of functional hepatocytes for regenerative medicine and drug discovery.

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