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Drug Delivery: Mesoporous Silica Supraparticles for Sustained Inner‐Ear Drug Delivery (Small 21/2014)
Author(s) -
Wang Yajun,
Wise Andrew K.,
Tan Justin,
Maina James W.,
Shepherd Robert K.,
Caruso Frank
Publication year - 2014
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.201470132
Subject(s) - mesoporous silica , drug delivery , materials science , nanotechnology , mesoporous material , cochlea , drug , inner ear , neurotrophic factors , nanoparticle , brain derived neurotrophic factor , chemistry , pharmacology , neuroscience , medicine , psychology , organic chemistry , biochemistry , receptor , catalysis
Mesoporous silica supraparticles (MS‐SPs) self‐assembled from mesoporous silica nanoparticles are reported on page 4244 by F. Caruso and co‐workers. The MS‐SPs are effective carriers for the sustained delivery of brain‐derived neurotrophic factor. Animal studies show that the MS‐SPs can be implanted into the cochlea and deliver neurotrophins to prevent the progressive loss of the auditory neurons that normally occurs with deafness.